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Makale Tam Makale Uluslararası 2014

The Risk Evaluation of Tungsten Oxide Nanoparticles in Cultured Rat Liver Cells for Its Safe Applications in Nanotechnology

Hasan Türkez, Erdal Sönmez, Ozlem TURKEZ, Yousef Ibrahem Mokhtar, Antonio di Stefano, Guven TURGUT

Brazilian Archives of Biology and Technology Cilt 57 · Sayı 4 · ss. 532–541 · 01.07.2014
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Özet

Tungsten (VI) oxide (WO3) nanoparticles (NPs) are used for many industrial purposes in everyday life. However, their effects on human health have not been sufficiently evaluated. Therefore, the present study was designed to investigate the toxicity potentials of various concentrations (0 to 1000 ppm) of WO3 NPs (< 100 nm particle size) in cultured primary rat hepatocytes. The results of cell viability assay showed that the higher concentrations of dispersed WO3 NPs (300, 500 and 1000 ppm) caused significant (p< 0.05) decreases of cell viability. Also, dose dependent negative alterations were observed in oxidative status and antioxidant capacity levels after the application of WO3 in cultured rat primary hepatocytes. The results of genotoxicity tests revealed that these NPs did not cause significant increases of micronucleated hepatocytes (MNHEPs) but increased 8-oxo-2-deoxyguanosine (8-OH-dG) levels as compared to the control culture.

Anahtar kelimeler

oxidative stress IN-VITRO GENOTOXICITY cytotoxicity HUMAN BLOOD TITANIUM-DIOXIDE Boron compounds Tungsten oxide Aflatoxin B-1 human lymphocytes HEPATOCYTES nanotoxicity CARBIDE NANOPARTICLES ROS GENERATION HEPATOMA-CELLS

Sürdürülebilir Kalkınma Amaçları

  • SKA 3: Sağlıklı Bireyler

Atıf için künye

Türkez, H., Sönmez, E., TURKEZ, O., Mokhtar, Y. I., di Stefano, A., & TURGUT, G. (2014). The Risk Evaluation of Tungsten Oxide Nanoparticles in Cultured Rat Liver Cells for Its Safe Applications in Nanotechnology. Brazilian Archives of Biology and Technology, 57(4), 532–541. https://doi.org/10.1590/s1516-89132014005000021

BibTeX 
@article{turkez2014-151436,
  author = {Türkez, Hasan and Sönmez, Erdal and TURKEZ, Ozlem and Mokhtar, Yousef Ibrahem and di Stefano, Antonio and TURGUT, Guven},
  title = {The Risk Evaluation of Tungsten Oxide Nanoparticles in Cultured Rat Liver Cells for Its Safe Applications in Nanotechnology},
  journal = {Brazilian Archives of Biology and Technology},
  year = {2014},
  volume = {57},
  number = {4},
  pages = {532--541},
  issn = {1516-8913},
  doi = {10.1590/s1516-89132014005000021},
  url = {https://akademik.atauni.edu.tr/yayinlar/151436-the-risk-evaluation-of-tungsten-oxide-nanoparticles-in-cultured-rat-liver-cells}
}