Patients with dental calculus have increased saliva and gingival crevicular fluid fetuin-A levels but no association with fetuin-A polymorphisms
Özet
Fetuin-A is a potent inhibitor of calcium-phosphate precipitation and of the calcification process, therefore it can also be related with dental calculus. Thus, we aimed to investigate a possible relationship between fetuin-A gene polymorphism and the presence of dental calculus. A possible relationship between serum, saliva and gingival crevicular fluid (GCF) levels of fetuin-A was also investigated. Fetuin-A c.742C > T and c.766C > G polymorphisms were investigated in 103 patients with or without dental calculus. Additionally, serum, saliva and GCF fetuin-A levels of patients were compared according to dental calculus presence. A significant difference was not observed in the distribution of the fetuin-A c.742C > T and c.766C > G polymorphisms between patients with or without dental calculus. Saliva and GCF fetuin-A concentrations of patients with dental calculus were statistically higher than those without dental calculus (P=0.001, P=0.036 respectively). According to our results, fetuin-A c.742C > T and c.766C > G polymorphisms were not associated with presence of dental calculus. However, higher GCF and saliva fetuin-A levels were detected in patients with dental calculus than in patients without dental calculus, which may result from an adaptive mechanism to inhibit mineral precipitation and eventually calculus formation.
Anahtar kelimeler
Atıf için künye
Dogan, G. E., Demir, T., Laloğlu, E., SAĞLAM, E., AKSOY, H., YILDIRIM, A., & AKÇAY, F. (2016). Patients with dental calculus have increased saliva and gingival crevicular fluid fetuin-A levels but no association with fetuin-A polymorphisms. BRAZILIAN ORAL RESEARCH, 30. https://doi.org/10.1590/1807-3107bor-2016.vol30.0129
BibTeX
@article{dogan2016-14279,
author = {Dogan, Gulnihal Emrem and Demir, Turgut and Laloğlu, Esra and SAĞLAM, Ebru and AKSOY, Hülya and YILDIRIM, Abdulkadir and AKÇAY, Fatih},
title = {Patients with dental calculus have increased saliva and gingival crevicular fluid fetuin-A levels but no association with fetuin-A polymorphisms},
journal = {BRAZILIAN ORAL RESEARCH},
year = {2016},
volume = {30},
issn = {1807-3107},
doi = {10.1590/1807-3107bor-2016.vol30.0129},
url = {https://akademik.atauni.edu.tr/yayinlar/14279-patients-with-dental-calculus-have-increased-saliva-and-gingival-crevicular}
}