An Evaluation of Different Treatments for Recurrent Aphthous Stomatitis and Patient Perceptions: Nd:YAG Laser versus Medication

Objective: The aim of this randomized controlled clinical trial was to determine the anxiety levels of patients with recurrent aphthous stomatitis (RAS) prior to therapy with the Nd:YAG laser or medication, and to compare the effects of these different treatment methods on the degree of post-treatment pain, discomfort, and functional complications (eating and speech) experienced. Materials and Methods: Twenty patients with RAS-related oral problems were included in the study. Levels of pre- and post- treatment pain and functional complications were assessed at patient visits on days 1, 4, and 7. Results: The results indicated that patients treated with the Nd: YAG laser had less post- treatment pain and fewer functional complications, and reported immediate relief of pain and faster healing (p < 0.05). However, only after 5 d was there a significant reduction in the pain levels of the patients treated with medication. Conclusion: Our results suggest that the Nd: YAG laser has better patient acceptance, shorter treatment time, and lower rates of pain and post- treatment adverse events among patients with RAS.