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Makale Tam Makale Uluslararası 2019

Evaluation of New Bone Formation Using Autogenous Tooth Bone Graft Combined with Platelet-Rich Fibrin in Calvarial Defects

ALPER KIZILDAĞ, Ufuk Tasdemir, Taner Arabacı, ÖZLEM ÖZMEN, Canan Aksu Kizildag, Berrin Iyilikci

JOURNAL OF CRANIOFACIAL SURGERY Cilt 30 · Sayı 6 · ss. 1662–1666 · 01.09.2019
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Özet

The purpose of the present study was to evaluate the contributions of autogenous tooth bone graft (ATBG) combined with platelet-rich fibrin (PRF) on new bone formation and bone morphogenetic protein (BMP)-2 in rabbit calvarial defects. Twelve male New Zealand rabbits were used in this study. Three circular bone defects were prepared in each rabbit with a drill. These defects were divided into 3 groups: control, treated with ATBG, and treated with ATBG+PRF. The animals were sacrificed at 28 days. Samples were evaluated by histomorphometric analyses and total augmented area, new bone area and bone density were calculated. In addition, expression of BMP-2 was determined by immunohistochemical staining. The total augmented area, new bone area and bone density were significantly greater in the ATBG group than in the control group (P<0.05). Also, these values were significantly higher in the ATBG+PRF group than the ATBG group (P<0.05). Test groups demonstrated significantly increased BMP-2 levels compared with the control group (P<0.05). The present study suggested that ATBG combined with PRF significantly increased the new bone formation and enhanced bone healing in cranial defects.

Anahtar kelimeler

AUGMENTATION ALLOGRAFT EXPRESSION platelet-rich fibrin IMPLANTS Growth factors INTRABONY DEFECTS bone formation tooth graft CALCIUM-PHOSPHATE CERAMICS DENTIN MATRIX calvarial defects SOCKETS RABBITS

Atıf için künye

KIZILDAĞ, A., Tasdemir, U., Arabacı, T., ÖZMEN, Ö., Kizildag, C. A., & Iyilikci, B. (2019). Evaluation of New Bone Formation Using Autogenous Tooth Bone Graft Combined with Platelet-Rich Fibrin in Calvarial Defects. JOURNAL OF CRANIOFACIAL SURGERY, 30(6), 1662–1666. https://doi.org/10.1097/scs.0000000000005413

BibTeX 
@article{kizildag2019-13897,
  author = {KIZILDAĞ, ALPER and Tasdemir, Ufuk and Arabacı, Taner and ÖZMEN, ÖZLEM and Kizildag, Canan Aksu and Iyilikci, Berrin},
  title = {Evaluation of New Bone Formation Using Autogenous Tooth Bone Graft Combined with Platelet-Rich Fibrin in Calvarial Defects},
  journal = {JOURNAL OF CRANIOFACIAL SURGERY},
  year = {2019},
  volume = {30},
  number = {6},
  pages = {1662--1666},
  issn = {1049-2275},
  doi = {10.1097/scs.0000000000005413},
  url = {https://akademik.atauni.edu.tr/yayinlar/13897-evaluation-of-new-bone-formation-using-autogenous-tooth-bone-graft-combined-with}
}