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Makale Tam Makale Uluslararası 2020

A biochemical and immunohistochemical study of the effects of caffeic acid phenethyl ester on alveolar bone loss and oxidative stress in diabetic rats with experimental periodontitis

Alper Kızıldağ, Taner Arabacı, Mevlüt Albayrak, Havva Müge Balseven, Canan Aksu Kızıldağ, Ufuk Tasdemir

Biotechnic and Histochemistry Cilt 95 · Sayı 6 · ss. 456–463 · 01.08.2020
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Özet

Caffeic acid phenethyl ester (CAPE) is used as a therapeutic agent to prevent bone loss. We determined the effects of systemically administered CAPE on alveolar bone loss and oxidative stress in diabetic rats with experimental periodontitis. Forty male rats were divided into four equal groups: control, experimental periodontitis (EP), EP-diabetes mellitus (EP-DM) and EP-DM-CAPE. DM was induced by streptozotocin, then lipopolysaccharide was injected to induce periodontitis. CAPE was administered to the EP-DM-CAPE group daily for 15 days. Then, serum samples were taken and the rats were sacrificed for histological analyses. Serum interleukin (IL-1 beta) and oxidative stress also were evaluated. Alveolar bone loss was assessed histomorphometrically. Alveolar bone loss and IL-1 beta levels were significantly less in the EP-DM-CAPE and EP groups compared to the EP-DM group. Oxidative stress was significantly less in the EP-DM-CAPE group compared to the EP and EP-DM groups. Receptor activator of nuclear factor kappa-B ligand (RANKL) levels were significantly higher in the EP-DM group compared to the disease groups. CAPE significantly reduced RANKL levels in the EP-DM-CAPE group compared to the EP-DM group. We found that CAPE treatment significantly inhibited DM induced oxidative stress and RANKL induced osteoclastogenesis and alveolar bone loss in diabetic rats with periodontitis.

Anahtar kelimeler

RESORPTION DIABETES-MELLITUS oxidative stress GINGIVAL CREVICULAR FLUID MELLITUS ALVEOLAR BONE PERIODONTITIS Serum melatonin ANTIOXIDANTS LIPID-PEROXIDATION rats ANTIOXIDANT ENZYMES TNF-ALPHA KAPPA-B INTERLEUKIN-1

Sürdürülebilir Kalkınma Amaçları

  • SKA 3: Sağlıklı Bireyler

Atıf için künye

Kızıldağ, A., Arabacı, T., Albayrak, M., Balseven, H. M., Aksu Kızıldağ, C., & Tasdemir, U. (2020). A biochemical and immunohistochemical study of the effects of caffeic acid phenethyl ester on alveolar bone loss and oxidative stress in diabetic rats with experimental periodontitis. Biotechnic and Histochemistry, 95(6), 456–463. https://doi.org/10.1080/10520295.2020.1718756

BibTeX 
@article{kizildag2020-13871,
  author = {Kızıldağ, Alper and Arabacı, Taner and Albayrak, Mevlüt and Balseven, Havva Müge and Aksu Kızıldağ, Canan and Tasdemir, Ufuk},
  title = {A biochemical and immunohistochemical study of the effects of caffeic acid phenethyl ester on alveolar bone loss and oxidative stress in diabetic rats with experimental periodontitis},
  journal = {Biotechnic and Histochemistry},
  year = {2020},
  volume = {95},
  number = {6},
  pages = {456--463},
  issn = {1052-0295},
  doi = {10.1080/10520295.2020.1718756},
  url = {https://akademik.atauni.edu.tr/yayinlar/13871-a-biochemical-and-immunohistochemical-study-of-the-effects-of-caffeic-acid}
}