Total, free, and bioavailable 25-hydroxyvitamin D levels in patients with periodontitis (stage III): a case–control study

Aydın, Tuğba; Dilsiz, Alparslan; Özkal Eminoğlu, Didem; ŞAHİN, Ahmet Bedreddin; Laloğlu, Esra; Bayrakdar, Yunus Emre

doi:10.1007/s00784-022-04844-9

Makale Tam Makale Uluslararası 2023

Total, free, and bioavailable 25-hydroxyvitamin D levels in patients with periodontitis (stage III): a case–control study

Tuğba Aydın, Alparslan Dilsiz, Didem Özkal Eminoğlu, Ahmet Bedreddin ŞAHİN, Esra Laloğlu, Yunus Emre Bayrakdar

CLINICAL ORAL INVESTIGATIONS Cilt 27 · Sayı 1 · ss. 421–430 · 01.01.2023

DOI ile aç

Özet

© 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.Objective: The aim of this study was to investigate the relationship between total, free and bioavailable 25-hydroxyvitamin D levels, and periodontitis. Materials and methods: Thirty-nine patients with periodontitis diagnosis and 44 healthy participants were included in this study. 25-Hydroxyvitamin D, vitamin D-binding protein, procalcitonin, and albumin levels were measured from the serum samples obtained. Free and bioavailable 25-hydroxyvitamin D levels were calculated. Total, free, and bioavailable 25-hydroxyvitamin D levels were compared between the healthy control and periodontitis groups. The association of total 25 (OH)D levels with periodontitis was tested through univariate analysis and multivariate logistic regression. Results: Total 25-hydroxyvitamin D, bioavailable 25-hydroxyvitamin D, and free 25-hydroxyvitamin D levels were significantly lower in the periodontitis group than in the healthy control group (p < 0.001). In the logistic regression analysis, a significant correlation was observed between total 25-hydroxyvitamin D and periodontitis (p<0.001). Conclusion: Our study shows that there is a relationship between total, free and bioavailable 25-hydroxyvitamin D levels and periodontitis. In addition, it has been shown that the determination of free and bioavailable 25-hydroxyvitamin D levels does not provide additional advantages in terms of the relationship between periodontitis and vitamin D. Clinical relevance: In this case–control study, we examined the relationship between total, free and bioavailable 25-hydroxyvitamin D and periodontitis. We found lower total, free, and bioavailable 25-hydroxyvitamin D levels in periodontitis patients. It was also found that vitamin D-binding protein may be an important biomarker in the identification of various forms of periodontal disease. Trial registration: ClinicalTrials.gov Identifier NCT05343273.

Anahtar kelimeler

PERIODONTITIS Bioavailability Vitamin D Vitamin D-binding protein

Atıf için künye

Aydın, T., Dilsiz, A., Özkal Eminoğlu, D., ŞAHİN, A. B., Laloğlu, E., & Bayrakdar, Y. E. (2023). Total, free, and bioavailable 25-hydroxyvitamin D levels in patients with periodontitis (stage III): a case–control study. CLINICAL ORAL INVESTIGATIONS, 27(1), 421–430. https://doi.org/10.1007/s00784-022-04844-9

BibTeX

@article{aydin2023-13706,
  author = {Aydın, Tuğba and Dilsiz, Alparslan and Özkal Eminoğlu, Didem and ŞAHİN, Ahmet Bedreddin and Laloğlu, Esra and Bayrakdar, Yunus Emre},
  title = {Total, free, and bioavailable 25-hydroxyvitamin D levels in patients with periodontitis (stage III): a case–control study},
  journal = {CLINICAL ORAL INVESTIGATIONS},
  year = {2023},
  volume = {27},
  number = {1},
  pages = {421--430},
  issn = {1432-6981},
  doi = {10.1007/s00784-022-04844-9},
  url = {https://akademik.atauni.edu.tr/yayinlar/13706-total-free-and-bioavailable-25-hydroxyvitamin-d-levels-in-patients-with}
}