The importance of the glucose-to-lymphocyte ratio in patients with hepatocellular carcinoma treated with sorafenib
Özet
Aim: To show the prognostic significance of the glucose-to-lymphocyte ratio (GLR) in hepatocellular carcinoma (HCC). Patients & methods: A total of 150 patients with advanced HCC who were treated with sorafenib in our center between January 2011 and December 2019 were included in the study retrospectively. Neutrophil-to-lymphocyte ratio, systemic immune-inflammation index, lymphocyte-to-monocyte ratio, platelet-to-lymphocyte ratio, prognostic nutritional index and GLR were analyzed to assess their prognostic value using Kaplan-Meier and Cox regression analysis before and after propensity score matching (PSM). Results: In univariate analysis before and after PSM, albumin-bilirubin grade, neutrophil-to-lymphocyte ratio, systemic immune-inflammation index, lymphocyte-to-monocyte ratio, prognostic nutritional index, AFP level and GLR were found to be significantly associated with both progression-free and overall survival. In multivariate analysis before and after PSM, GLR, albumin-bilirubin grade and AFP were determined to be independent prognostic factors for progression-free and overall survival. Conclusion: The GLR prior to sorafenib treatment is a new prognostic biomarker that may predict survival in advanced HCC.
Anahtar kelimeler
Atıf için künye
Yılmaz, A., Şimşek, M., Hannarici, Z., Buyukbayram, M. E., Bilici, M., & Tekin, S. B. (2021). The importance of the glucose-to-lymphocyte ratio in patients with hepatocellular carcinoma treated with sorafenib. FUTURE ONCOLOGY, 17(33), 4545–4559. https://doi.org/10.2217/fon-2021-0457
BibTeX
@article{yilmaz2021-118934,
author = {Yılmaz, Ali and Şimşek, Melih and Hannarici, Zekeriya and Buyukbayram, Mehmet E. and Bilici, Mehmet and Tekin, Salim B.},
title = {The importance of the glucose-to-lymphocyte ratio in patients with hepatocellular carcinoma treated with sorafenib},
journal = {FUTURE ONCOLOGY},
year = {2021},
volume = {17},
number = {33},
pages = {4545--4559},
issn = {1479-6694},
doi = {10.2217/fon-2021-0457},
url = {https://akademik.atauni.edu.tr/yayinlar/118934-the-importance-of-the-glucose-to-lymphocyte-ratio-in-patients-with}
}