Article 2025 · 0 citations

The Effects of Galangin Mitigating Doxorubicin-Induced Hepatorenal Injury

Ekinci Akdemir, Fazile Nur, Guler, Mustafa Can, Eraslan, Ersen, Tanyeli, Ayhan, Yildirim, Serkan, Kandemir, Fatih Mehmet, Kucukler, Sefa

Abstract

This study investigates the protective effects of galangin (GAL) against doxorubicin (Dox)-induced hepatorenal toxicity in a rat model, focusing on oxidative stress, inflammation, and key markers, including interleukin-6 (IL-6), 8-hydroxydeoxyguanosine (8-OHdG), and aquaporin-1 (AQP-1). Male Sprague-Dawley rats were divided into four groups: Control, Dox, Dox+GAL 50 mg/kg, and Dox+GAL 100 mg/kg. GAL significantly attenuated Dox-induced damage by reducing IL-6 and 8-OHdG levels, restoring AQP-1 expression, and improving histopathological profiles. Biochemical analysis demonstrated GAL's antioxidant activity, evidenced by elevated levels of glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT), alongside decreased levels of malondialdehyde (MDA). These findings suggest GAL as a potential therapeutic agent for mitigating Dox-induced organ toxicity, with broader implications for conditions involving oxidative stress and inflammation.

Keywords

doxorubicin galangin hepatorenal injury inflammation oxidative stress CISPLATIN-INDUCED NEPHROTOXICITY OXIDATIVE STRESS INFLAMMATION APOPTOSIS LIVER

WoS Categories

Biochemistry & Molecular Biology Toxicology

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
Year: 2025
Volume: 40
Issue: 1
ISSN: 1095-6670
eISSN: 1099-0461
DOI: 10.1002/jbt.70669
WoS UID: WOS:001650046100001

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