Article 2025 · 0 atıf

The Effects of Galangin Mitigating Doxorubicin-Induced Hepatorenal Injury

Ekinci Akdemir, Fazile Nur, Guler, Mustafa Can, Eraslan, Ersen, Tanyeli, Ayhan, Yildirim, Serkan, Kandemir, Fatih Mehmet, Kucukler, Sefa

Özet

This study investigates the protective effects of galangin (GAL) against doxorubicin (Dox)-induced hepatorenal toxicity in a rat model, focusing on oxidative stress, inflammation, and key markers, including interleukin-6 (IL-6), 8-hydroxydeoxyguanosine (8-OHdG), and aquaporin-1 (AQP-1). Male Sprague-Dawley rats were divided into four groups: Control, Dox, Dox+GAL 50 mg/kg, and Dox+GAL 100 mg/kg. GAL significantly attenuated Dox-induced damage by reducing IL-6 and 8-OHdG levels, restoring AQP-1 expression, and improving histopathological profiles. Biochemical analysis demonstrated GAL's antioxidant activity, evidenced by elevated levels of glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT), alongside decreased levels of malondialdehyde (MDA). These findings suggest GAL as a potential therapeutic agent for mitigating Dox-induced organ toxicity, with broader implications for conditions involving oxidative stress and inflammation.

Anahtar Kelimeler

doxorubicin galangin hepatorenal injury inflammation oxidative stress CISPLATIN-INDUCED NEPHROTOXICITY OXIDATIVE STRESS INFLAMMATION APOPTOSIS LIVER

WoS Kategorileri

Biochemistry & Molecular Biology Toxicology

Sürdürülebilir Kalkınma Amaçları

Sağlık ve Kaliteli Yaşam

Künye

Dergi: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
Yıl: 2025
Cilt: 40
Sayı: 1
ISSN: 1095-6670
eISSN: 1099-0461
DOI: 10.1002/jbt.70669
WoS UID: WOS:001650046100001

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