Review 2025 · 1 citations

Targeting PKLR in liver diseases

Yuan, Meng, Shi, Mengnan, Yang, Hong, Ashraf, Sajda, Iqbal, Shazia, Turkez, Hasan, Boren, Jan, Zhang, Cheng, Uhlen, Mathias, Altay, Ozlem, Mardinoglu, Adil

Abstract

Pyruvate kinase is a key regulator in hepatic glucose metabolism, encoded by the gene pyruvate kinase liver/red blood cells (PKLR). Systems biology-based approaches, including metabolic and gene co-expression networks analyses, as well as genome-wide association studies (GWAS), have led to the identification of PKLR as a pivotal gene influencing liver metabolism in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and hepatocellular carcinoma (HCC). Here, we review the critical role of PKLR in MASLD and HCC progression and examine the effects of PKLR modulation both in vitro and in vivo. We also discuss the development of therapeutic strategies for patients with MASLD and HCC by modulating PKLR, highlighting its promising future in a broader range of liver diseases.

Keywords

GENE-EXPRESSION CYCLIN D1 LIRAGLUTIDE SEMAGLUTIDE INHIBITORS STEATOSIS WEIGHT DESIGN

WoS Categories

Endocrinology & Metabolism

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: TRENDS IN ENDOCRINOLOGY AND METABOLISM
Year: 2025
Volume: 36
Issue: 12
Pages: 1099-1110
ISSN: 1043-2760
eISSN: 1879-3061
DOI: 10.1016/j.tem.2025.03.009
WoS UID: WOS:001635591800001

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