Boren, Jan

Synthesis of novel tetrahydrobenzo[b]thiophene-3-carbonitrile (THBTC)-based heterocycles: Structural insights, reactivity profiles, and in-silico bioactivity studies

Targeting PKLR in liver diseases

Integrative proteo-transcriptomic characterization of advanced fibrosis in chronic liver disease across etiologies

Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats

Multi-omics characterization of improved cognitive functions in Parkinson's disease patients after the combined metabolic activator treatment: a randomized, double-blinded, placebo-controlled phase II trial

Multi-omics analysis reveals the key factors involved in the severity of the Alzheimer's disease

Discovery of Cell-Permeable Allosteric Inhibitors of Liver Pyruvate Kinase: Design and Synthesis of Sulfone-Based Urolithins

Discovery of therapeutic agents targeting PKLR for NAFLD using drug repositioning ( vol 83 , 104214 , 2022)

Combined metabolic activators improve metabolic functions in the animal models of neurodegenerative diseases (Retraction of Vol 314, art no 121325, 2023)

Synthesis, spectroscopic characterization, DFT and molecular docking of N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl) naphthalene-1-sulfonamide derivatives

Design and synthesis of novel JNK inhibitors targeting liver pyruvate kinase for the treatment of non-alcoholic fatty liver disease and hepatocellular carcinoma

Combined Metabolic Activators with Different NAD+ Precursors Improve Metabolic Functions in the Animal Models of Neurodegenerative Diseases

Combined metabolic activators improve metabolic functions in the animal models of neurodegenerative diseases

The acute effect of different NAD plus precursors included in the combined metabolic activators

Longitudinal metabolomics analysis reveals the acute effect of cysteine and NAC included in the combined metabolic activators

Revisiting the role of serine metabolism in hepatic lipogenesis

Ellagic Acid and Its Metabolites as Potent and Selective Allosteric Inhibitors of Liver Pyruvate Kinase

Combined metabolic activators improve cognitive functions in Alzheimer's disease patients: a randomised, double-blinded, placebo-controlled phase-II trial

Discovery of therapeutic agents targeting <i>PKLR </i>for <i>NAFLD </i>using drug repositioning

Prediction of drug candidates for clear cell renal cell carcinoma using a systems biology-based drug repositioning approach

Multiomics Analysis Reveals the Impact of Microbiota on Host Metabolism in Hepatic Steatosis

A network-based approach reveals the dysregulated transcriptional regulation in non-alcoholic liver disease

Multi-omics approaches for revealing the complexity of cardiovascular disease

Combined Metabolic Activators Decrease Liver Steatosis by Activating Mitochondrial Metabolism in Hamsters Fed with a High-Fat Diet

Stratification of patients with clear cell renal cell carcinoma to facilitate drug repositioning

Combined Metabolic Activators Accelerates Recovery in Mild-to-Moderate COVID-19

Integrative transcriptomic analysis of tissue-specific metabolic crosstalk after myocardial infarction

Addressing the heterogeneity in liver diseases using biological networks

Informing Pharmacokinetic Models With Physiological Data: Oral Population Modeling of L-Serine in Humans

Discovery of Functional Alternatively Spliced <i>PKM</i> Transcripts in Human Cancers