Article 2025 · 15 citations

Preparation, characterization and antibacterial investigation of water-soluble curcumin-chitooligosaccharide complexes

Zhai, Xingchen, Guo, Yu, Shang, Man, Guo, Ziyan, Ren, Difeng, Abd El-Aty, A. M.

Abstract

Curcumin has a wide range of application prospects, with various bioactivities in the food industry and in the biomedical field. However, curcumin has poor water solubility and is sensitive to pH, light and temperature. In this study, curcumin-chitooligosaccharide (CUR-COS) complexes were prepared via mechanochemical methods, and the CUR-COS complex was more soluble after freeze-drying (up to 862-fold greater than that of curcumin). The complex was characterized by SEM, XRD, FT-IR and thermal analysis, and its stability against pH, light and thermal treatment was evaluated. COSs could serve as carriers for curcumin delivery. Additionally, the antibacterial activity of the formed complex was determined. As a result, CUR-COS exhibited significantly better water solubility, enhanced stability, and stronger antibacterial properties than did pure CUR, offering a promising pathway for the extensive application of lipophilic natural products in foods, especially water-based products.

Keywords

Curcumin Chitooligosaccharides Complexation Solubility Antibacterial activity NANOSTRUCTURED LIPID CARRIERS X-RAY-DIFFRACTION BETA-CYCLODEXTRIN ESCHERICHIA-COLI STABILITY NANOPARTICLES MECHANISM

WoS Categories

Chemistry, Applied Chemistry, Organic Polymer Science

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: CARBOHYDRATE POLYMERS
Year: 2025
Volume: 351
ISSN: 0144-8617
eISSN: 1879-1344
DOI: 10.1016/j.carbpol.2024.123083
WoS UID: WOS:001372200900001

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