Phytochemical analysis and biological evaluation of essential oils and extracts from <i>Heracleum pastinacifolium</i> subsp. <i>incanum</i> (Boiss. & A.Huet) PHDavis, an endemic plant from Turkey
Yuca, Hafize, Sefali, Abdurrahman, Aydin, Bilge, Karadayi, Mehmet, Gulsahin, Yusuf, Yazici, Aysenur, Karakaya, Songul, Demirci, Betuel, Coban, Furkan, Ozdemir, Erkan, Demir, Abdussamed Yasin, Guvenalp, Zuhal
Essential oil content of and phenolic compounds flower-fruit, root, and aerial parts of Heracleum pastinacifolium subsp. incanum were analysed by GC/MS and LC/MS methods, respectively. Antidiabetic, anticholinesterase, and antioxidant activities of flower-fruit, root, aerial parts methanol extracts were evaluated. Apiole (35.0%), myristicine (72.2%), and myristicine (15.1%) were found as major compounds of fruit-flower mixture, root, aerial part essential oils, respectively. Hesperidin was found the highest amount in aerial part and flower-fruit extracts with 8904.2621 ng/mL and 11558.3634 ng/mL values, respectively. Fruit-flower extract showed the highest activity against alpha-glucosidase (24%). Root extract demonstrating the highest activity (18%) against AChE enzyme. Flowers-fruits mixture methanol extract had a higher % inhibition value on ABTS(<middle dot>+) and DPPH center dot. Flowers-fruits mixture methanol extract was rich in total phenol, total tannin, and protein content. All the extracts were determined as genetoxically safe according to the results of Ames/Salmonella, Escherichia coli WP2 and Allium cepa assays.
- Journal
- NATURAL PRODUCT RESEARCH
- Year
- 2025
- Volume
- 39
- Issue
- 22
- Pages
- 6421-6431
- ISSN
- 1478-6419
- eISSN
- 1478-6427
- DOI
- 10.1080/14786419.2024.2372661
- WoS UID
- WOS:001263044300001