Article
2024
·
1 citations
An Efficient Promising Direction for the Synthesis of Dispirotripiperazine (6-6-6 DSTP) Core
Abstract
A new and facile route for the one-pot synthesis of 3,12-dicyano-3,6,9,12-tetraazadispiro[5.2.5(9).2(6)]hexadecane-6,9-diium dibromide as a dispirotripiperazine source was introduced by the simple reaction of 1,4-diazabicyclo[2.2.2]octane (DABCO) with cyanogen bromide (BrCN) under mild condition at room temperature. The hydrolysis of dicyanamide moieties in the prepared dispiro compound gave 3,12-diaza-6,9-diazoniadispiro[5.2.5.2]hexadecane dibromide with the dispirotripiperazine (6-6-6) core. The molecular structure of the new compound was characterized by FT-IR, H-1, C-13, HSQC NMR spectroscopy, mass and CHN analysis, and X-ray crystallography technique.
Keywords
dispirotripiperazine
cyanogen bromide
DABCO
one pot
DRUG
WoS Categories
Chemistry, Organic
Sustainable Development Goals
Citation
- Journal
- SYNTHESIS-STUTTGART
- Year
- 2024
- Volume
- 56
- Issue
- 17
- Pages
- 2742-2746
- ISSN
- 0039-7881
- eISSN
- 1437-210X
- DOI
- 10.1055/s-0043-1774930
- WoS UID
- WOS:001255063800001