An Efficient Promising Direction for the Synthesis of Dispirotripiperazine (6-6-6 DSTP) Core

A new and facile route for the one-pot synthesis of 3,12-dicyano-3,6,9,12-tetraazadispiro[5.2.5(9).2(6)]hexadecane-6,9-diium dibromide as a dispirotripiperazine source was introduced by the simple reaction of 1,4-diazabicyclo[2.2.2]octane (DABCO) with cyanogen bromide (BrCN) under mild condition at room temperature. The hydrolysis of dicyanamide moieties in the prepared dispiro compound gave 3,12-diaza-6,9-diazoniadispiro[5.2.5.2]hexadecane dibromide with the dispirotripiperazine (6-6-6) core. The molecular structure of the new compound was characterized by FT-IR, H-1, C-13, HSQC NMR spectroscopy, mass and CHN analysis, and X-ray crystallography technique.

Dergi

SYNTHESIS-STUTTGART

Yıl

2024

Cilt

56

Sayı

17

Sayfa

2742-2746

ISSN

0039-7881

eISSN

1437-210X

DOI

10.1055/s-0043-1774930

WoS UID

WOS:001255063800001

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