Development of a biocompatible green drug release system using salidroside-TiO2-doped chitosan oligosaccharide molecularly imprinted polymers
Liu, Zijie, Ma, Xingbin, Li, Shuyu, Qiu, Jiajie, Liu, Siyu, Huang, Zhifeng, Lin, Hongling, Abd El-Aty, A. M.
This study focuses on creating a green drug release system using a food-grade titanium dioxide (TiO2) material through surface molecular imprinting. Salidroside (SD) was chosen as the template molecule to synthesize molecularly imprinted polymers (SDT-MIP) utilizing TiO2-doped chitosan oligosaccharides as the functional monomer. The SDT-MIPs were characterized using multiple techniques, and their effectiveness was evaluated through an in vitro release study. Additionally, the affinity of SDT-MIPs toward the template molecule was examined using Langmuir and Freundlich adsorption models. The Langmuir model revealed a maximum capacity of 170.41 mg/g and an imprinted factor of 3.4. The study demonstrated that drug release from the SDT-MIPs in simulated gastrointestinal fluid primarily occurred through pure Fick diffusion. The release kinetics exhibited diffusion coefficients ranging from 3.38 x 10-3 cm2/s to 2.78 x 10-2 cm2/s, indicating their biocompatibility and potential application in drug delivery. Furthermore, the SDT-MIP demonstrated no adverse impact on cell viability even at concentrations as high as 1000 lg/mL. The survival rate of cells cultivated in the presence of SDT-MIP solution exceeded 120 & PLUSMN; 12.46%,
- Journal
- ARABIAN JOURNAL OF CHEMISTRY
- Year
- 2023
- Volume
- 16
- Issue
- 10
- ISSN
- 1878-5352
- eISSN
- 1878-5379
- DOI
- 10.1016/j.arabjc.2023.105130
- WoS UID
- WOS:001043707700001