Article 2023 · 3 citations

Effects of <i>Polygonum cognatum</i> Meissn. extract on indomethacin induced gastric damage in rats

Bayir, Yasin, Tagiyeva, Nermin, Albayrak, Abdulmecit, Ismayilov, Abbas, Akpinar, Erol, Toktay, Erdem, Karaoglan, Esen Sezen, Memmedova, Kushver, Halici, Zekai, Rustemova, Nilufar

Abstract

We investigated the anti-ulcer activity of ethanol extracts of Polygonum cognatum on indomethacin induced gastric damage in rats. We evaluated the number of ulcer areas, oxidant and antioxidant parameters as well as histopathologic features in rat stomach. We measured the total antioxidant status of P. cognatum in concentrations from 1.56-100 mg/ml. P. cognatum extract inhibited indomethacin induced ulcer formation with an effect similar to a 20 mg/kg dose of the standard anti-ulcer drug, esomeprazole. All doses of P. cognatum extract exhibited positive effects on oxidative stress markers and histopathological features in the stomach tissue of rats. We suggest that the antioxidant activity of P. cognatum extract may be responsible for its gastroprotective effect and that P. cognatum extract may be a useful gastroprotective agent.

Keywords

Antioxidants phytotherapy Polygonum cognatum rat stomach ulcer OXIDATIVE STRESS ULCER ACID ASSAY

WoS Categories

Biotechnology & Applied Microbiology Cell Biology

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: BIOTECHNIC & HISTOCHEMISTRY
Year: 2023
Volume: 98
Issue: 6
Pages: 424-431
ISSN: 1052-0295
eISSN: 1473-7760
DOI: 10.1080/10520295.2023.2221040
WoS UID: WOS:001003241600001

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