Article 2023 · 3 atıf

Effects of <i>Polygonum cognatum</i> Meissn. extract on indomethacin induced gastric damage in rats

Bayir, Yasin, Tagiyeva, Nermin, Albayrak, Abdulmecit, Ismayilov, Abbas, Akpinar, Erol, Toktay, Erdem, Karaoglan, Esen Sezen, Memmedova, Kushver, Halici, Zekai, Rustemova, Nilufar

Özet

We investigated the anti-ulcer activity of ethanol extracts of Polygonum cognatum on indomethacin induced gastric damage in rats. We evaluated the number of ulcer areas, oxidant and antioxidant parameters as well as histopathologic features in rat stomach. We measured the total antioxidant status of P. cognatum in concentrations from 1.56-100 mg/ml. P. cognatum extract inhibited indomethacin induced ulcer formation with an effect similar to a 20 mg/kg dose of the standard anti-ulcer drug, esomeprazole. All doses of P. cognatum extract exhibited positive effects on oxidative stress markers and histopathological features in the stomach tissue of rats. We suggest that the antioxidant activity of P. cognatum extract may be responsible for its gastroprotective effect and that P. cognatum extract may be a useful gastroprotective agent.

Anahtar Kelimeler

Antioxidants phytotherapy Polygonum cognatum rat stomach ulcer OXIDATIVE STRESS ULCER ACID ASSAY

WoS Kategorileri

Biotechnology & Applied Microbiology Cell Biology

Sürdürülebilir Kalkınma Amaçları

Sağlık ve Kaliteli Yaşam

Künye

Dergi: BIOTECHNIC & HISTOCHEMISTRY
Yıl: 2023
Cilt: 98
Sayı: 6
Sayfa: 424-431
ISSN: 1052-0295
eISSN: 1473-7760
DOI: 10.1080/10520295.2023.2221040
WoS UID: WOS:001003241600001

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