Review 2022 · 5 citations

Sepsis: Immunopathology, Immunotherapies, and Future Perspectives

Abstract

Sepsis is a syndrome that includes physiological, pathological, and biochemical abnormalities resulting from the host immune response to infection. Despite the improved treatment modalities in recent years, the incidence and mortality of sepsis are still increasing. Sepsis immunopathology is increasingly attracting the attention of researchers. The successes experienced with immunotherapeutics in the treatment of cancer and coronavirus disease 2019, which are diseases with similar pathophysiological features and common immune defects with sepsis, have given rise to the hope that similar successes can be achieved in the treatment of sepsis. In this review, future perspectives on the immunopathology of sepsis and immunotherapeutics are presented to improve the current understanding of the disease.

Keywords

Sepsis immunotherapy immunopathology TUMOR-NECROSIS-FACTOR SEPTIC SHOCK DOUBLE-BLIND INDUCED IMMUNOSUPPRESSION MONOCLONAL-ANTIBODY ANTIOXIDANT ENZYMES IMMUNE DYSFUNCTION IMPROVES SURVIVAL CECAL LIGATION RAT MODEL

WoS Categories

Medicine, General & Internal

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: EURASIAN JOURNAL OF MEDICINE
Year: 2022
Volume: 54
Pages: S127-S132
eISSN: 1308-8742
DOI: 10.5152/eurasianjmed.2022.22314
WoS UID: WOS:000926902700019

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