Article 2021 · 10 citations

A novel class for carbonic anhydrases inhibitors and evaluation of their non-zinc binding

Kuzu, Burak, Tan, Meltem, Gulcin, Ilhami, Menges, Nurettin

Abstract

In this study, 23 different imidazole derivatives were synthesized, and the inhibitory properties of these derivatives against carbonic anhydrase I and II isoenzymes were investigated for the first time. The inhibition concentrations of the imidazole derivatives were found to be in the range of 2.89-115.5 nM. Docking studies examined the binding properties of the imidazole derivatives, and the structure-activity relationship is discussed. Theoretical calculations showed that the binding mode of the imidazole ring was non-zinc binding.

Keywords

carbonic anhydrase inhibition docking imidazole ring non-zinc binding SAR study ISOENZYMES I ISOZYME-I DERIVATIVES CLONING XII SULFONAMIDE IMIDAZOLE MECHANISM COUMARIN TARGET

WoS Categories

Chemistry, Medicinal Chemistry, Multidisciplinary Pharmacology & Pharmacy

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: ARCHIV DER PHARMAZIE
Year: 2021
Volume: 354
Issue: 10
ISSN: 0365-6233
eISSN: 1521-4184
DOI: 10.1002/ardp.202100188
WoS UID: WOS:000658294300001

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