Article 2022 · 64 atıf

Multiomics Analysis Reveals the Impact of Microbiota on Host Metabolism in Hepatic Steatosis

Zeybel, Mujdat, Arif, Muhammad, Li, Xiangyu, Altay, Ozlem, Shi, Mengnan, Akyildiz, Murat, Saglam, Burcin, Gonenli, Mehmet Gokhan, Yigit, Buket, Ulukan, Burge, Ural, Dilek, Shoaie, Saeed, Turkez, Hasan, Nielsen, Jens, Zhang, Cheng, Uhlen, Mathias, Boren, Jan, Mardinoglu, Adil, Yang, Hong

Özet

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a complex disease involving alterations in multiple biological processes regulated by the interactions between obesity, genetic background, and environmental factors including the microbiome. To decipher hepatic steatosis (HS) pathogenesis by excluding critical confounding factors including genetic variants and diabetes, 56 heterogenous MAFLD patients are characterized by generating multiomics data including oral and gut metagenomics as well as plasma metabolomics and inflammatory proteomics data. The dysbiosis in the oral and gut microbiome is explored and the host-microbiome interactions based on global metabolic and inflammatory processes are revealed. These multiomics data are integrated using the biological network and HS's key features are identified using multiomics data. HS is finally predicted using these key features and findings are validated in a follow-up cohort, where 22 subjects with varying degree of HS are characterized.

Anahtar Kelimeler

gut and oral metagenomics metabolic dysfunction-associated fatty liver disease metabolomics multiomics analysis proteomics systems biology systems medicine FATTY LIVER-DISEASE INTESTINAL MICROBIOTA GUT MICROBIOME DIET INFLAMMATION OBESITY NAFLD ACID ASSOCIATION INCREASES

WoS Kategorileri

Chemistry, Multidisciplinary Nanoscience & Nanotechnology Materials Science, Multidisciplinary

Sürdürülebilir Kalkınma Amaçları

Sağlık ve Kaliteli Yaşam

Künye

Dergi: ADVANCED SCIENCE
Yıl: 2022
Cilt: 9
Sayı: 11
eISSN: 2198-3844
DOI: 10.1002/advs.202104373
WoS UID: WOS:000751803900001

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