Boyuttan verimliliğe: Fe3O4 Tabanlı İlaç Nanotaşıyıcılarının Yapısal Profili

<table class="group" id="form_group_" style="font-family: Verdana, Helvetica, Arial, sans-serif; font-size: 12px; overflow: auto; border: 1px solid rgb(0, 0, 0); width: 1504.40625px; background-color: rgb(224, 224, 224); margin-bottom: 5px; caret-color: rgb(0, 0, 0);"><tbody><tr style="font-size: 9pt;"><td width="5%" style="font-size: 9pt;"> </td><td width="50%" align="left" style="font-size: 9pt;">The primary objective of this study is to investigate the effects of particle size on the structural and chemical characteristics of cisplatin-loaded Fe₃O₄ nanoparticles using synchrotron-based techniques. Specifically, the project aims to synthesized Fe₃O₄ nanoparticles in different size ranges (18-28nm and 50-100 nm) with cisplatin through surface functionalization in our laboratory. .

In scope of proposal is to

1. determine the oxidation states and local chemical environments of iron (Fe) and platinum (Pt) atoms in the nanoparticle-drug formulation using X-ray Absorption Spectroscopy (XAS), including: Fe K-edge (to assess Fe²⁺/Fe³⁺ ratio) and Pt L₃-edge (to assess coordination and oxidation state of cisplatin after loading),

2. compare drug loading efficiency and bonding behavior as a function of particle size and surface properties.

3. correlate structural integrity and chemical composition with potential performance in drug delivery, especially regarding size-dependent cellular uptake and release behavior.

4. provide insights into the design of more effective magnetic nanoparticle-based drug carriers, contributing to the development of next-generation nanotheranostics with improved efficacy and reduced side effects.</td></tr></tbody></table>