Article 2026 · 0 citations

The Course of Progranulin Levels at Admission and During Early Period of Insulin Treatment in Children with Newly Diagnosed Type 1 Diabetes Mellitus

Donmez, Ayse Sena, Cayir, Atilla, Laloglu, Esra, Ozkaya, Alev Lazoglu, Disci, Esra, Kaya, Serap Kilic, Kasali, Kamber, Koca, Serkan Bilge, Demirbilek, Huseyin

Abstract

Objective Progranulin (PGRN), a growth factor, modulates cell proliferation, wound repair, and inflammation. It is also involved in glucose metabolism and is associated with insulin resistance and diabetes mellitus (DM). In the present study, PGRN levels were measured at admission and during follow-up in children with newly diagnosed type 1 DM (T1DM) and compared to healthy controls. Methods Children with T1DM and healthy controls were included. The age, weight, height, body mass index (BMI), severity of acidosis, glucose, insulin, C-peptide, and diabetes-specific autoantibodies of children with newly diagnosed T1DM were collected. PGRN was measured in children with T1DM at admission, at first week of follow-up, and in healthy controls. Results A total of 49 children were included; 25 with T1DM [12 Female/13 Male (12F/13M)] and 24 healthy controls (10F/14M). There was no differences in age (11 +/- 3.9 years vs 12.1 +/- 3.1 years, p=0.269) and BMI standard deviation (SD) score (-0.11 +/- 1.49 SD vs. 0.10 +/- 0.82 SD, p=0.540) of children with T1DM and healthy controls. The mean basal PGRN level of children with newly diagnosed T1DM was higher than in controls (90.8 +/- 17.3 ng/mL vs. 30 +/- 11.5 ng/mL, p<0.001). In children with T1DM, mean basal PGRN at admission had declined significantly (58.4 +/- 16.9 ng/mL; p<0.001) in the first week after glycemic regulation was achieved but remained significantly higher than in controls (p<0.001). Conclusion These findings suggest that elevated PGRN levels in children with newly diagnosed T1DM may reflect either an acute inflammatory response to diabetic ketoacidosis or a persistent alteration in metabolic regulation, or both of these, highlighting the potential role of PGRN as a biomarker in the early course of T1DM.

Keywords

Diabetic ketoacidosis pediatric progranulin PGRN type 1 diabetes mellitus GROWTH-FACTOR EPITHELIN PRECURSOR SERUM PROGRANULIN COMPLICATIONS ACROGRANIN

WoS Categories

Endocrinology & Metabolism Pediatrics

Citation

Journal: JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
Year: 2026
Volume: 18
Issue: 1
Pages: 123-128
ISSN: 1308-5727
eISSN: 1308-5735
DOI: 10.4274/jcrpe.galenos.2025.2025-3-9
WoS UID: WOS:001718615600001

Open via DOI