Adrenocortical carcinoma presenting with extensive striae: A case report and literature review

Adrenocortical tumors are rare tumors in childhood. Virilization is the most common symptom, but about 5.5% of patients may also present with isolated Cushing's syndrome. A girl 15 years and 8 months of age presented with complaints of striae on her legs, acne for 2 weeks, and amenorrhea for 2 months. On physical examination, extensive striae were observed on her legs and abdomen. On hormonal investigation, her adrenocorticotropic hormone level was <5 pg/ml, cortisol was 35.4 & micro;g/dl. Her hypercortisolism raised suspicion of Cushing's syndrome. Adrenal MRI revealed a right adrenal mass approximately 9 cm in diameter. Pleural metastasis was detected and the patient was diagnosed as having stage 4 adrenocortical carcinoma. Despite treatment, she died 9 months after diagnosis. Our case followed an aggressive clinical course and was unique due to the presence of extensive striae without pronounced virilization or Cushingoid symptoms.

Journal

INDIAN JOURNAL OF CANCER

Year

2025

Volume

62

Issue

4

Pages

548-551

ISSN

0019-509X

eISSN

1998-4774

DOI

10.4103/ijc.ijc_87_24

WoS UID

WOS:001708773600007