Article 2026 · 0 citations

Protective effects of zingerone on the retina in diabetic rats

Utlu, Bahadir, Kozan, Betul Dertsiz, Yildirim, Serkan

Abstract

circle AIM: To investigate the effects of zingerone (ZO) on the retina in diabetic rats. circle METHODS: A total of 70 rats were randomly selected and divided into seven groups [diabetic group (Dm+; n=10), diabetic+metformin group (Dm+Met; n=10), diabetic+ZO25 group (Dm+ZO 2 5 ; n= 10 ), diabetic +ZO 5 0 group (Dm+ZO 50; n=10), diabetic+metform in group+ZO 50 Group (Dm+Met+ZO50; n=10)]. Diabetes was induced by streptozotocin (STZ), and metformin and two different doses of ZO were administered via gavage. Retinal tissues were evaluated by histopathological and immunohistochemical analyses. circle RESULTS: In diabetic rats, severe retinal inflammation, tissue necrosis, and increased tumor necrosis factor-alpha (TNF-alpha) expression were observed. ZO administration reduced these effects in a dose-dependent manner. Protective effects of metformin alone were limited, and no synergistic benefit was observed in ZO+Met groups. Administration of 50 mg/kg ZO to non-diabetic rats caused no retinal toxicity. Additionally, elevated 8-OHdG and c-Jun N-terminal kinase (JNK) expressions in diabetic retinopathy models were significantly reduced by ZO treatment. circle CONCLUSION: ZO can markedly reduce the pathological effects of the retina in a diabetic rat model.

Keywords

retina diabetic retinopathy rat zingerone PATHOGENESIS INFLAMMATION RETINOPATHY

WoS Categories

Ophthalmology

Citation

Journal: INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
Year: 2026
Volume: 19
Issue: 3
Pages: 455-461
ISSN: 2222-3959
eISSN: 2227-4898
DOI: 10.18240/ijo.2026.03.04
WoS UID: WOS:001704949400004

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