Article 2026 · 0 citations

Electrochemical C-H trifluoromethylation of 4-phenylthiazol-2-amines

Yesilyurt, Isa, Dagalan, Ziya, Anil, Baris, Kocak, Ramazan, Bayrakceken Nisanci, Fatma, Nisanci, Bilal

Abstract

Herein, we report a new methodology for the electrochemical oxidative C-H trifluoromethylation of 4-phenylthiazol-2-amines in an undivided cell using a glassy carbon electrode (GCE) and sodium trifluoromethanesulfinate (CF3SO2Na; Langlois' reagent) as the CF3 radical source. Using this tert-butyl hydroperoxide (TBHP)-mediated and transition metal-free effective approach, trifluo-romethylated 4-phenylthiazol-2-amines were synthesized in high yields (up to 97%).

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Chemistry, Organic

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Climate Action Good Health and Well-being

Citation

Journal: ORGANIC & BIOMOLECULAR CHEMISTRY
Year: 2026
Volume: 24
Issue: 7
Pages: 1434-1439
ISSN: 1477-0520
eISSN: 1477-0539
DOI: 10.1039/d5ob01958c
WoS UID: WOS:001675299400001

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