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Article 2025 · 12 citations

A human pan-disease blood atlas of the circulating proteome

Alvez, Maria Bueno, Bergstrom, Sofia, Kenrick, Josefin, Johansson, Emil, Aberg, Mikael, Akyildiz, Murat, Altay, Ozlem, Skold, Hilda, Antonopoulos, Konstantinos, Apostolakis, Emmanouil, Balcioglu, Yasin Hasan, Bergstrom, Anna, Bergstrom, Goran, Bjorkander, Sophia, Brage, Suzanne Egyhazi, Brodin, Petter, Butler, Lynn, Cajander, Sara, Danielsson, Hanna, Dayangac, Murat, Dinler-Doganay, Gizem, Doganay, Levent, Enblad, Gunilla, Enblad, Malin, Fagerberg, Linn, Falck-Jones, Sara, Farnert, Anna, Forsberg, Mattias, Gonzalez, Laura, Gummesson, Anders, Gunnarsson, Karin, Gunnarsson, Iva, Gyllensten, Ulf, Hesselager, Goran, Hober, Andreas, Hoglund, Martin, Holmqvist, Marie, Horuluoglu, Begum, Hultgren, Rebecka, Iglesias, Maria Jesus, Janols, Helena, Johansson, Fredric, Johnsson, Anette, Klareskog, Lars, Kotol, David, Kull, Inger, Kvarnstrom, Marika, Lautenbach, Maximilian Julius, Liljedahl, Ulrika, Lindman, Henrik, Lindskog, Cecilia, Lipcsey, Miklos, Lundberg, Ingrid E., Mardinoglu, Adil, Melen, Erik, Meng, Lingqi, Merritt, Anne-Sophie, Mulder, Jan, Nguyen, Mai Thi-Huyen, Nordlund, Jessica, Norrby-Teglund, Anna, Notarnicola, Antonella, Nowak, Piotr, Odeberg, Jacob, Oksvold, Per, Olsson, Tomas, Padyukov, Leonid, Pauksens, Karlis, Piehl, Fredrik, Pin, Elisa, Ponten, Fredrik, Rameika, Natallia, Reepalu, Anton, Roy, Joy, Schwenk, Jochen M., Sen, Meltem, Siika, Antti, Simonson, Oscar E., Sivertsson, Asa, Sjoblom, Tobias, Sjostedt, Evelina, Skoglund, Lovisa, Smed-Sorensen, Anna, Sonden, Klara, Sonnerborg, Anders, Stalberg, Karin, Stralin, Kristoffer, Sunden-Cullberg, Jonas, Sundling, Christopher, Sutantiwanichkul, Thanadol, Svedman, Fernanda Costa, Svensson, Mattias, Svenungsson, Elisabet, Lakshmikanth, Tadepally, Tran-Minh, Khue Hua, Turkez, Hasan, Unge, Christian, Venge, Per, Wahren-Herlenius, Marie, Woessmann, Jakob, Yang, Hong, Yesilkaya, Umit Haluk, Yuan, Meng, Zeybel, Mujdat, Zhang, Cheng, Zhong, Wen, Zwahlen, Martin, Von Feilitzen, Kalle, Nilsson, Peter, Edfors, Fredrik, Uhlen, Mathias

Abstract

The human blood proteome provides a holistic readout of health states through the assessment of thousands of circulating proteins. In this study, we present a pan-disease resource to enable the study of diverse disease phenotypes within a harmonized proteomics dataset. By profiling protein concentrations across 59 diseases and healthy cohorts, we identified proteins associated with age, sex, and body mass index, as well as disease-specific signatures. This study highlights shared and distinct protein patterns across conditions, demonstrating the power of a unified proteomics approach to uncover biological insights. The dataset, covering 8262 individuals and up to 5416 proteins, serves as an online resource for exploring disease-specific protein profiles and advancing precision medicine research.

Keywords
BODY-MASS INDEX BIOMARKER-DISCOVERY LEPTIN LEVELS SERUM LEPTIN PLASMA CANCER GENETICS DIFFERENTIATION ASSOCIATIONS CHILDREN
WoS Categories
Multidisciplinary Sciences
Sustainable Development Goals
Citation
Journal
SCIENCE
Year
2025
Volume
390
Issue
6779
ISSN
0036-8075
eISSN
1095-9203
DOI
10.1126/science.adx2678
WoS UID
WOS:001643421200001
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