Review 2025 · 0 citations

Effects of omega-3 fatty acids (n-3 PUFAs) on cardiovascular and muscular health across various populations: a review of supplementation benefits

Palabiyik, Ahmet Alperen, Palabiyik, Esra

Abstract

PurposeThis review examines the effects and clinical relevance of omega-3 fatty acids (n-3 PUFAs) on cardiovascular and muscular health.MethodsA structured literature search was conducted in PubMed, Web of Science, and Scopus for studies published between 2020 and 2024, using keywords such as "eicosapentaenoic acid," "docosahexaenoic acid," "cardiovascular health," and "muscle function."ResultsClinical trials and meta-analyses show that omega-3 supplementation reduces triglycerides and total cholesterol, improves endothelial function and blood pressure, and contributes to plaque stabilization through anti-inflammatory mechanisms. Evidence also suggests muscular benefits, including support for protein synthesis, reduced inflammation, enhanced recovery, and mitigation of age-related muscle loss. Synergistic effects have been reported when combined with protein, vitamin D, or plant-derived compounds such as sesame and Nigella sativa.Conclusionn-3 PUFAs may support cardiovascular and muscular health across diverse populations. While evidence is promising, supplementation should be individualized, and further research is needed to establish optimal dosing and long-term safety.

Keywords

Alpha-linolenic acid Eicosapentaenoic acid N-3 PUFAs Docosahexaenoic acid Supplementation Muscle function Endothelial function POLYUNSATURATED FATTY-ACIDS ALPHA-LINOLENIC ACID OLDER-ADULTS MUSCLE DISEASE MECHANISMS OUTCOMES HYPERTENSION MARKERS RISKS

WoS Categories

Food Science & Technology Nutrition & Dietetics

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: NUTRIRE
Year: 2025
Volume: 50
Issue: 2
eISSN: 2316-7874
DOI: 10.1186/s41110-025-00381-z
WoS UID: WOS:001587398500001

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