Article 2025 · 6 citations

Synthesis and Bioactivity Evaluation of Novel Sulfonamide-1,2,3-Triazole Hybrids: <i>In Vitro</i> and <i>In Silico</i> Studies

Cesme, Mustafa, Onur, Sultan, Ozgeris, Fatma Betul, Tumer, Ferhan

Abstract

Novel hybrid compounds, incorporating 4-iodosulfonamide and 1,2,3-triazole units, were synthesized and characterized using FT-IR, NMR, and elemental analysis. Their antioxidant (ABTS, DPPH, Cuprac), cholinesterase inhibition (AChE, BuChE), and anticancer (Caco-2, PC3) activities were evaluated. In DPPH assays, compounds 13, 6, and 11 showed superior antioxidant activity compared to alpha-tocopherol and BHT. Compound 6 exhibited the highest ABTS activity, while compound 9 excelled in Cuprac assays. For cholinesterase inhibition, compounds 8 and 13 outperformed Galantamine against AChE, and compound 9 showed the strongest BuChE inhibition. Antiproliferative studies revealed compound 13's effectiveness against PC3 and compound 9 against Caco-2. Comprehensive ADMET analysis indicated favorable pharmaceutical properties, including oral absorption via the BBB and GI tract. In silico molecular docking supported these findings, confirming the therapeutic potential of these hybrid structures.

Keywords

alzheimer anticancer activity in silico sulfonamides triazole ANTICANCER ACTIVITY DERIVATIVES INHIBITORS TRIAZOLES

WoS Categories

Biochemistry & Molecular Biology Chemistry, Medicinal

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: CHEMICAL BIOLOGY & DRUG DESIGN
Year: 2025
Volume: 106
Issue: 1
ISSN: 1747-0277
eISSN: 1747-0285
DOI: 10.1111/cbdd.70155
WoS UID: WOS:001536277100001

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