Serum Ang 1, Ang 1-7, and Mas levels as potential biomarkers in obstructive sleep apnea syndrome
Cil, Gizem, Araz, Omer, Kerget, Bugra, Laloglu, Esra, Aksakal, Alperen, Yilmazel Ucar, Elif, Saglam, Leyla
AimsIn obstructive sleep apnea (OSA), the balance between inflammatory and anti-inflammatory responses is disrupted. This study examined the association between serum angiotensin 1 (Ang 1), angiotensin 1-7 (Ang 1-7), and Mas receptor levels and OSA severity. Material and methodsA total of 190 subjects underwent polysomnography and serum analysis for Ang 1, Ang 1-7, and Mas using ELISA. Patients were classified into control, mild, moderate, and severe OSA groups based on AHI. ResultsAng 1-7, Ang 1, and serum Mas levels were significantly lower in moderate and severe OSA groups compared to control and mild OSA (p < 0.001). Negative correlations were found between these biomarkers and AHI (e.g. Ang 1-7: R = -0.597, p < 0.001). ROC analysis showed strong diagnostic performance: AUC was 0.864 for Ang 1-7, 0.873 for Ang 1, and 0.837 for Mas, with sensitivity of 98%, 98%, and 97%, respectively. ConclusionReduced levels of Ang 1-7, Ang 1, and Mas are associated with increased OSA severity. These biomarkers demonstrated high diagnostic value and may be useful in stratifying patients with moderate-to-severe OSA.
- Journal
- BIOMARKERS IN MEDICINE
- Year
- 2025
- Volume
- 19
- Issue
- 14
- Pages
- 613-621
- ISSN
- 1752-0363
- eISSN
- 1752-0371
- DOI
- 10.1080/17520363.2025.2525059
- WoS UID
- WOS:001521072500001