Article 2025 · 0 citations

A comparative evaluation of salivary and plasma bisphenol-A levels in patients released from four different orthodontic appliances: ultra-performance liquid chromatography-mass spectrometry study. A non-randomized clinical trial

Cik, Serdar, Kilic, Nihat, Atila, Alptug

Abstract

Objective To evaluate the amount of bisphenol-A (BPA) released from different orthodontic appliances into saliva and plasma and to compare BPA levels between orthodontic appliance groups. Methods This non-randomized clinical trial included 78 patients, and they were divided into four groups: fixed appliance, temporary anchorage devices (TADs), removable appliance, and functional appliance groups. Saliva and plasma samples were collected before treatment/appliance wear (T0) and one day (T1), one week (T2), and one month (T3) after treatment/appliance wear. Saliva and plasma BPA levels were analysed using Ultra-performance Liquid Chromatography-Mass Spectrometry (UPLC-MS/MS). Data was analysed using analysis of variance (ANOVA) and Tukey HSD multiple comparison tests with Bonferroni correction. Correlations between saliva and plasma BPA levels at different time points were evaluated using Pearson correlation analysis. Results BPA levels ranged from 0.07-7.28 ng/ml in saliva samples and from 0.17-12.51 ng/ml in plasma samples in all groups. Within-group comparisons showed no significant changes over time (p > 0.0125) in each group. Between-group comparisons showed significantly higher saliva BPA levels in the fixed appliance group compared to the other groups (p < 0.017), with no significant differences in plasma BPA levels between groups (p < 0.0175). Positive correlations were observed between saliva BPA measurements, whereas positive correlation was observed only between T0 and T3 plasma PBA levels. Conclusion This research obviously demonstrated that the orthodontic appliances we investigated release BPA into the saliva. However, the BPA levels detected in both saliva and plasma are consistently within the acceptable safety limits. However, precautions should be taken to minimize BPA release during orthodontic treatment.

Keywords

bisphenol-A (BPA) orthodontic appliances saliva plasma UPLC-MS/MS endocrine disruptor dental materials ESTROGENICITY METABOLISM EXPOSURE

WoS Categories

Dentistry, Oral Surgery & Medicine

Sustainable Development Goals

Clean Water and Sanitation Good Health and Well-being

Citation

Journal: EUROPEAN JOURNAL OF ORTHODONTICS
Year: 2025
Volume: 47
Issue: 3
ISSN: 0141-5387
eISSN: 1460-2210
DOI: 10.1093/ejo/cjaf021
WoS UID: WOS:001471438800001

Open via DOI