Response of different infection models in broiler chickens against supplemental Organic acid-A review

Antimicrobial resistance in microorganisms has emerged as a significant issue in the domain of animal husbandry, leading to the prohibition of sub-therapeutic antibiotics in feed and necessitating the exploration of alternative growth promoters. Organic acids have garnered considerable attention as prospective substitutes, proffering analogous advantages to antibiotics without exacerbating resistance. Nonetheless, their effectiveness against a spectrum of pathogenic infections remains ambiguous. Consequently, this review scrutinizes the efficacy of organic acids in experimental infection models, encompassing necrotic enteritis (Clostridium perfringens), coccidiosis (Eimeria spp.), Pullorum disease (Salmonella spp.), Campylobacteriosis (Campylobacter jejuni), and Colibacillosis (Escherichia coli). The analysis indicates that organic acids exhibit promising outcomes across various infection models. For instance, in trials concerning necrotic enteritis, organic acid supplementation diminished C. perfringens colonization and enhanced intestinal health. Likewise, in investigations of coccidiosis, organic acids alleviated Eimeria-induced damage and improved growth performance. In the context of infections caused by Salmonella and E. coli, these additives displayed considerable antimicrobial efficacy, leading to diminished pathogen loads and an improvement in various indicators of animal health. The review also delineates several proposed mechanisms through which organic acids exert their effects against these pathogens, encompassing direct antimicrobial actions, modulation of gastrointestinal pH, and the augmentation of the host's immune response. These findings imply that organic acids may represent feasible alternatives to antibiotics within animal feed, potentially addressing the concurrent challenges associated with growth promotion and pathogen management. Nonetheless, additional research is imperative to refine dosages, combinations, and delivery methodologies for optimal effectiveness across diverse species and production systems. This thorough evaluation offers significant insights into the formulation of effective, antibiotic-free approaches in animal nutrition and health management.

Journal

MICROBIAL PATHOGENESIS

Year

2025

Volume

204

ISSN

0882-4010

eISSN

1096-1208

DOI

10.1016/j.micpath.2025.107527

WoS UID

WOS:001468621800001