Article 2025 · 2 citations

Evaluation of Hematological and Biochemical Parameters that Predict the No-reflow Phenomenon in Patients Undergoing Primary Percutaneous Coronary Intervention

Aydemir, Selim, Aydin, Sidar Siyar, Altinkaya, Onur, Aksakal, Emrah, Ozmen, Murat

Abstract

Acute coronary syndromes (ACS) are one of the most common causes of morbidity and mortality worldwide. Primary percutaneous coronary intervention (pPCI) is the main treatment strategy to restore myocardial perfusion. However, the no-reflow phenomenon (NRP) may block coronary flow. The present study focused on assessing and contrasting predictive parameters for NRP in ACS patients. Our research is a retrospective analysis. We assessed the parameters significantly associated with NRP using Cox regression and Receiver operating characteristic (ROC) Curve analysis. The study included 5122 patients who met the criteria. The average age of the patients was 63.9 + 13.2, and 74.4% were male. It was observed that NRP developed in 1.8% of all patients. Age, hemoglobin (Hb), white blood cell (WBC), glucose and low density lipoprotein cholesterol (LDL-C) were determined to be independent predictors of NRP. The power of these parameters to predict NRP was similar, and WBC was the most predictive (Area Under Curve (AUC): 0.605 95% CI: 0.539-0.671, P = .001). We believe that the use of these simple, practical, and routinely used hematological and biochemical parameters will help us predict the risk of developing NRP before pPCI. This information should improve management.

Keywords

acute coronary syndrome no-reflow phenomenon primary percutaneous coronary intervention ELEVATION MYOCARDIAL-INFARCTION TO-LYMPHOCYTE RATIO CELL DISTRIBUTION WIDTH ADVERSE CARDIAC EVENTS LONG-TERM OUTCOMES MICROVASCULAR OBSTRUCTION NEUTROPHIL/LYMPHOCYTE RATIO D-DIMER NEUTROPHIL MORTALITY

WoS Categories

Peripheral Vascular Disease

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: ANGIOLOGY
Year: 2025
Volume: 76
Issue: 10
Pages: 999-1009
ISSN: 0003-3197
eISSN: 1940-1574
DOI: 10.1177/00033197251320141
WoS UID: WOS:001422717800001

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