Fixed-Dose Antiplatelet Dual Combination in Patients with Coronary Artery Disease in Turkish Population: DAPT-TR
Oz, Ahmet, Toprak, Kenan, Aydin, Ertan, Sarac, Ibrahim, Dogdus, Mustafa, Opan, Selcuk, Yenercag, Mustafa, Tascanov, Mustafa Begenc, Kumet, Omer, Karaagac, Mirac, Ozmen, Murat, Murat, Bektas, Kertmen, Omer, Bekler, Ozkan, Inci, Sinan, Huyut, Mustafa Ahmet, Ozderya, Ahmet, Er, Fahri, Duran, Mustafa, Ardahanli, Isa, Bas, Mehmet Memduh, Guzel, Tuncay, Ceyhun, Gokhan, Ozdemir, Ibrahim Halil, Ozen, Mehmet Burak, Gunduz, Ramazan, Erdogan, Aslan, Cetin, Ilyas, Baris, Veysel Ozguer, Yayla, Cagri, Karaduman, Medeni, Askin, Lutfu, Bekar, Lutfu, Tanriverdi, Okan, Ozkan, Eyup, Yesil, Emrah, Caliskan, Serhat, Kuzu, Zulfiye, Uguz, Berat, Boyuk, Ferit, Kunak, Aysegul Ulgen, Murat, Selda, Asil, Serkan, Kayhan, Ozkan, Erdogan, Emrah, Duz, Ramazan, Katkat, Fahrettin, Ekin, Tuba, Ibisoglu, Ersin, Ates, Bilge Nazar, Ayca, Burak, Ergene, Asim Oktay, Zoghi, Mehdi
Background: Dual antiplatelet therapy (DAPT) is the treatment of choice for patients with acute and chronic coronary syndromes as it reduces mortality and prevents recurrent thrombotic complications. The assessment of both ischaemic burden and bleeding risk is crucial in deciding which DAPT to choose and how long it should be continued. Objectives: The aim of our study was to perform prospective clinical follow-up of patients receiving fixed-dose combination therapy (ASA 75 mg + clopidogrel 75 mg). Our study is a multicentric, cross-sectional, observational, cohort study. Methods: A total of 1500 patients who were started on fixed-dose combination DAPT for acute or chronic coronary syndrome were included in the study. Primary endpoints were hospitalization for any reason, hospitalization for cardiovascular cause, acute myocardial infarction, stent thrombosis, target vessel revascularization and bleeding; the secondary endpoints were death for any reason or cardiovascular cause and stroke. The significance level adopted in the statistical analysis was 5%. Results: Median age was 63 years; 78.5% of the patients were receiving DAPT treatment for acute coronary syndrome. The rates of hospitalization for cardiovascular reasons, acute myocardial infartion, stent thrombosis and target-vessel revascularization were 7.9%, 2.3%, 1.3% and 4.2%, respectively. While the rate of BARC type 1 bleeding was 3.3%, the rate of BARC type 5, 3, or 2 bleeding was 0.6%. The secondary endpoints which were death from any cause, cardiovascular death and stroke were 0.5%, 0.3% and 0.3%, respectively. Conclusion: Our study shows that fixed-dose combination therapy is effective and safe in appropriately selected patients with acute or chronic coronary syndromes.
- Journal
- ARQUIVOS BRASILEIROS DE CARDIOLOGIA
- Year
- 2024
- Volume
- 121
- Issue
- 11
- ISSN
- 0066-782X
- eISSN
- 1678-4170
- DOI
- 10.36660/abc.20240202
- WoS UID
- WOS:001415844900001