Article 2024 · 12 citations

Quantification of Secondary Metabolites of <i>Satureja pilosa</i> (Lamiaceae) by LC-HRMS and Evaluation of Antioxidant and Cholinergic Activities

Kinoglu, Betul Kiraz, Gulcin, Ilhami, Goren, Ahmet C.

Abstract

In this study, secondary metabolite profiles of dichloromethane, acetone and methanol extracts of leaves and branches of Satureja pilosa species were determined by LC-HRMS. In-vitro inhibition activities of the obtained extracts against Alzheimer's disease (AD) which is a neurodegenerative disease were performed, and structure-activity relationships were discussed. While rosmarinic acid was found to be at the highest rate among the reported secondary metabolites in acetone and methanol extracts of the plant, penduletin was the secondary metabolite with the highest concentration in dichloromethane extract of the plant. The highest AChE inhibition was determined in leaf methanol extract with IC50: 41.2 +/- 5.6 mu g/mL, and the highest BChE inhibition was detected in leaf dichloromethane extract of the species with IC50: 52.3 +/- 8.6 mu g/mL concentration. Herein, total antioxidant capacities of the extracts were determined and reported by DPPH and ABTS radical scavenging and CUPRAC reducing ability methods.

Keywords

Satureja pilosa secondary metabolite LC-HRMS AChE BChE antioxidant CARBONIC-ANHYDRASE POLYPHENOL CONTENTS ANTICHOLINERGIC PROPERTIES INHIBITION PROFILES ACETYLCHOLINESTERASE L. BUTYRYLCHOLINESTERASE VULGARIS

WoS Categories

Plant Sciences Chemistry, Applied Chemistry, Medicinal

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: RECORDS OF NATURAL PRODUCTS
Year: 2024
Volume: 18
Issue: 6
Pages: 674-686
ISSN: 1307-6167
DOI: 10.25135/rnp.489.2410.3378
WoS UID: WOS:001385687300008

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