Assessing lipid-lowering and plasma cholesteryl ester transfer protein activity of <i>Centranthus longiflorus</i> and β-Sitosterol following administration to triton WR1339- treated rats

The aim of this study was to evaluate the lipid-lowering and plasma cholesteryl ester transfer protein(CETP) activity of Centranthus longiflorus(CL) and beta-Sitosterol(beta S) following intraperitoneal administration of Triton-WR 1339 (=Tyloxapol) (TWR) to male Wistar rats. Hyperlipidemia(HL) was developed by intraperitoneal injection of TWR. The animals were divided into main eight groups of six rats each. Rats were housed in separate cages and fed a standard diet for 7 days. After 7 days, ethanol extraction of CL plant, aqueous suspension of beta S and anacetrapib was given to rats by oral gavage 1 h before the triton injection. Blood samples were collected and used for the biochemical parameters analysis. Histopathological studies were also performed on liver tissue. In hyperlipidemic rats(HR), CL extract and beta S reduced total cholesterol similarly. beta S lowered low-density lipoprotein(LDL-C) more than CL extract. Both CL extract and beta S approximated impaired Alanine transaminase(ALT) and Aspartate transaminase(AST) levels in HR's to the level of control. CL extract provided better protection than beta S against deterioration in liver tissue samples seen in hyperlipidemic rats. Finally, CL extract and beta S inhibited CETP, at which point beta S was more effective. These findings showed that CL extract and beta S reduce plasma lipid concentration and may have a hypolipidemic effect due to their anti-CETP properties.

Journal

FOOD SCIENCE & NUTRITION

Year

2024

Volume

12

Issue

11

Pages

9788-9798

ISSN

2048-7177

DOI

10.1002/fsn3.4471

WoS UID

WOS:001339910800001