Article 2025 · 2 citations

Costunolide, an effective agent against oxidative damage, apoptosis and autophagy in the ovarian torsion/detorsion model

Akis, Pakistan Armin, Tanyeli, Ayhan, Akdemir, Fazile Nur Ekinci, Guler, Mustafa Can, Sebin, Saime Ozbek, Eraslan, Ersen, Laloglu, Esra, Comakli, Selim

Abstract

AimThis study assessed the efficacy of costunolide (COST) against oxidative tissue damage in the ovarian torsion/detorsion (TD) model.MethodologyAnimals were randomly assigned to sham, ovarian TD, COST 5 mg/kg + ovarian TD, and COST 10 mg/kg + ovarian TD groups. COST's effectiveness was determined by assessing oxidative stress markers, interleukin levels, and histopathological examinations.ResultsOxidative stress markers were elevated in the ovarian TD group compared to the sham group. COST treatment represented a decline compared to the TD group. Besides, the antioxidant activity was significantly higher in the ovarian TD group than in the sham group. COST treatment improved the antioxidant parameters compared to the TD group. Inflammatory parameters, such as tumour necrosis factor- alpha (TNF-alpha) and interleukin 1-beta (IL-1 beta) were higher in the ovarian TD group than the sham group.ConclusionCOST treatment suppressed the proinflammatory cytokine expression compared to the TD group. Histopathological data supported these findings.

Keywords

Costunolide oxidative tissue damage ovarian torsion/detorsion EXPRESSION INFLAMMATION PROGNOSIS CHILDREN TISSUES TORSION ASSAY

WoS Categories

Biochemistry & Molecular Biology Biophysics Endocrinology & Metabolism Physiology

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
Year: 2025
Volume: 131
Issue: 2
Pages: 265-273
ISSN: 1381-3455
eISSN: 1744-4160
DOI: 10.1080/13813455.2024.2407548
WoS UID: WOS:001320202500001

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