Article
2025
·
0 citations
Investigating the metabolic alterations of metastatic and local prostate cancer patients via PET/CT assisted untargeted metabolomics approach
Abstract
Prostate cancer is a very common and widespread health problem all over the world. It mostly metastases into bone tissues and pathogenesis become more complicated. In this study, it is aimed to explain etiopathogenesis of local and metastatic prostate cancer via untargeted metabolomics approach. The study was conducted by arranging 36 eligible patients. Their metastasis level were monitored via 68Ga-PSMA PET/CT. The large load of tumor cells mostly impacted phenylalanine, tyrosine, thiamin biosynthesis, aminoacyl t-RNA production, and energy metabolism. This PET/CT assisted metabolomics approach may lead to a new perspective on the pathogenesis of high tumour burden on metastasis.
Keywords
Metabolomics
PET/CT
Nuclear medicine
Radiopharmaceuticals
Cancer
POSITRON-EMISSION-TOMOGRAPHY
BONE-SCINTIGRAPHY
WoS Categories
Chemistry, Analytical
Chemistry, Inorganic & Nuclear
Nuclear Science & Technology
Sustainable Development Goals
Citation
- Journal
- JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
- Year
- 2025
- Volume
- 334
- Issue
- 1
- Pages
- 481-489
- ISSN
- 0236-5731
- eISSN
- 1588-2780
- DOI
- 10.1007/s10967-024-09760-8
- WoS UID
- WOS:001316781000008