Dysregulated Leukotriene Metabolism in Patients with COVID-19
Dogan, Halef Okan, Budak, Mahir, Dogan, Kubra, Zararsiz, Gozde Erturk, Yerlitas, Serra Ilayda, Bolat, Serkan, Senol, Onur, Buyuktuna, Seyit Ali, Pinarbasi, Ergun, Sariismailoglu, Ragip, Yavuz, Hayrettin
This study aimed to examine the leukotriene metabolism during COVID-19. In total, 180 participants were included in this study, of which 60 were healthy controls, 60 required intensive care units (ICU), and 60 did not require intensive care (non-ICU). The serum levels of 5-lipoxygenase (5-LO), 5-LO activating protein (ALOX5AP), and cysteinyl leukotriene (CYSLT) were measured, and the mRNA expression levels of 5-LO, ALOX5AP, and cysteinyl leukotriene receptor 1 (CYSLTR1) were investigated. Compared with the control group, both the non-ICU and ICU groups had lower levels of 5-LO and mRNA expression. ICU patients had lower levels of 5-LO and mRNA expression than non-ICU patients. CYSLTRI mRNA expression was highest in the ICU group, followed by the non-ICU group, and healthy controls had the lowest mRNA expression levels. CYSLT levels were higher in the control group than in the non-ICU and ICU groups. CYSLTRI expression was higher in patients than in controls; therefore, selective leukotriene receptor blockers can be used as treatment options. CYSLTR1 expression was higher in the ICU group than in the non-ICU group. Furthermore, CYSLTRI mRNA expression may be a promising biomarker of COVID-19 severity.
- Journal
- JAPANESE JOURNAL OF INFECTIOUS DISEASES
- Year
- 2024
- Volume
- 77
- Issue
- 3
- Pages
- 129-136
- ISSN
- 1344-6304
- eISSN
- 1884-2836
- DOI
- 10.7883/yoken.JJID.2023.211
- WoS UID
- WOS:001312464900002