Article 2025 · 2 citations

Reduction of 2-phenyl-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione with NaBH4: Investigation of<i> exo</i>-selectivity and reaction mechanism<i> via</i> theoretical computations

Gundogdu, Ozlem, Atalay, Abdurrahman, Turhan, Pinar, Anil, Baris, Sahin, Ertan, Bozkaya, Ugur, Kishali, Nurhan H., Kara, Yunus

Abstract

The reaction of the bicyclic imide with NaBH4 afforded acylaminocarbinol and carboxamide derivatives. The exact configuration of acylaminocarbinol 7 was determined by X-ray crystal analysis. Theoretical studies were carried out to explain the mechanism of the exo-selectivity observed in the first step of the reduction reaction and the formation of the secondary product in the second step. According to the obtained findings, i) in the first step of the reaction, the exo-path is kinetically more favorable, and ii) an alternative mechanism has been proposed instead of the mechanism proposed in the literature. The canonical forms of the amide group in the lactam ring were found to make an important contribution to the mechanism. iii) The amount of products formed in the reduction reaction depends on the reaction conditions.

Keywords

3-hydroxylactam Acylaminocarbinol Metal hydride reduction Bicyclic imide Theoretical computations CONVENIENT SYNTHESIS PHTHALIMIDES DERIVATIVES CONVERSION CANTHARIMIDE ANALOGS

WoS Categories

Chemistry, Physical

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: JOURNAL OF MOLECULAR STRUCTURE
Year: 2025
Volume: 1319
ISSN: 0022-2860
eISSN: 1872-8014
DOI: 10.1016/j.molstruc.2024.139520
WoS UID: WOS:001291687500001

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