Article 2024 · 6 citations

Syringic acid guards against indomethacin-induced gastric ulcer by alleviating inflammation, oxidative stress and apoptosis

Okkay, Irmak Ferah, Okkay, Ufuk, Cicek, Betul, Karatas, Ozhan, Yilmaz, Aysegul, Yesilyurt, Fatma, Hacimuftuoglu, Ahmet

Abstract

The purpose of this study was to evaluate the effects of syringic acid, an anti-oxidant, on indomethacin induced gastric ulcers in rats. Experimental groups were control, ulcer, ulcer treated with 20 mg/kg esomeprazole (a proton pump inhibitor that reduces acid secretion), and ulcer treated with 100 mg/kg syringic acid. Rats were pretreated with esomeprazole or syringic acid two weeks before ulcer induction. Our histopathological observations showed that either syringic acid or esomeprazole attenuated the severity of gastric mucosal damage. Moreover, syringic acid and esomeprazole pretreatments alleviated indomethacin-induced damage by regulating oxidative stress, inflammatory response, the level of transforming growth factor-beta (TGF-beta), expressions of COX and prostaglandin E2, cell proliferation, apoptosis and regulation of the NF-kappa B signaling pathway. We conclude that either esomeprazole or syringic acid administration protected the gastric mucosa from harmful effects of indomethacin. Syringic acid might, therefore be a potential therapeutic agent for preventing and treating indomethacin-induced gastric damage.

Keywords

Gastric ulcer indomethacin NF-kappa B oxidative stress syringic acid GASTROINTESTINAL-TRACT MOLECULAR-MECHANISMS INJURY CYCLOOXYGENASE ANTIOXIDANT PATHOGENESIS INHIBITION PROTECTION DAMAGE MICE

WoS Categories

Biotechnology & Applied Microbiology Cell Biology

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: BIOTECHNIC & HISTOCHEMISTRY
Year: 2024
Volume: 99
Issue: 3
Pages: 147-156
ISSN: 1052-0295
eISSN: 1473-7760
DOI: 10.1080/10520295.2024.2344477
WoS UID: WOS:001207014300001

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