Article 2024 · 12 citations

Catalyst/Metal/Solvent-Free Markovnikov Hydrothiolation of Unactivated Alkenes with Dithiocarbamic Acids

Halimehjani, Azim Ziyaei, Dagalan, Ziya, Marjani, Zahra, Gunduz, Figen, Dastan, Arif, Nisanci, Bilal

Abstract

Catalyst-free Markovnikov-selective hydrothiolation of unactivated alkenes still remains a great challenge. Herein, we develop a catalyst/metal/solvent-free methodology for the Markovnikov hydrothiolation of unactivated alkenes with in situ prepared dithiocarbamic acids, providing a wide array of alkyl dithiocarbamates. A variety of terminal, internal, cyclic, and acyclic unactivated alkenes were applied successfully in this protocol. This three-component thiol-ene reaction can be considered as a new family of click reactions.

Keywords

ONE-POT SYNTHESIS PHENYL SULFIDES 3-COMPONENT DERIVATIVES EFFICIENT OLEFINS THIOLS

WoS Categories

Chemistry, Organic

Citation

Journal: JOURNAL OF ORGANIC CHEMISTRY
Year: 2024
Volume: 89
Issue: 8
Pages: 5353-5362
ISSN: 0022-3263
eISSN: 1520-6904
DOI: 10.1021/acs.joc.3c02722
WoS UID: WOS:001195906800001

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