Review 2023 · 2 citations

Experimental In Vivo Toxicity Models for Alcohol Toxicity

Yoladi, Fatma Betul, Burmaoglu, Edanur, Palabiyik-Yucelik, Saziye Sezin

Abstract

Alcohol consumption poses a significant risk for the development of chronic illnesses, one of the leading causes of "preventable" disease and death worldwide. Harmful consumption of alcohol is thought to result in approximately 2.5-3 million deaths each year, the majority of which are caused by alcohol -related liver diseases. Hepatocellular carcinoma, cirrhosis, fibrosis, steatosis, and steatohepatitis are among the liver illnesses caused by alcohol. The mechanisms behind human diseases are often mimicked and understood through the use of animal models. Rodents are the ideal animals to study alcohol -related liver diseases. In these experimental models using rodents, the ethanol ratio, method of administration, and diet to be applied vary. Within the scope of this review, it is aimed at providing information about the experimental models used today for alcohol toxicity and the advantages and disadvantages of these models.

Keywords

Alcohol experimental animal model hepatotoxicity INDUCED OXIDATIVE STRESS INDUCED LIVER-INJURY MOUSE MODEL ANIMAL-MODELS INTRAGASTRIC INFUSION LIPID-PEROXIDATION TRANSGENIC MOUSE ETHANOL INTAKE FATTY LIVER DISEASE

WoS Categories

Medicine, General & Internal

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: EURASIAN JOURNAL OF MEDICINE
Year: 2023
Volume: 55
eISSN: 1308-8742
DOI: 10.5152/eurasianjmed.2023.23345
WoS UID: WOS:001194949900012

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