Biological Activities and Drug-Likeness Properties of Phenol-Based Heterocyclic Compounds
Yamali, Cem, Nenni, Merve, Sakarya, Mehtap Tugrak, Sakagami, Hiroshi, Gul, Halise Inci
The widespread use of small molecules having heterocyclic rings to design anticancer agents, and the antioxidant potential of their phenolic conjugates led us to investigate phenol-based heterocyclic compounds' anticancer, antioxidant activities, and drug-likeness properties. While compounds were evaluated in regards to cancer and non-cancer cell lines by the MTT method, antioxidant effects were carried out using the DPPH method. Drug-likeness properties were also evaluated using SwissADME software. The mean CC50 values were in the range 18.7 - >400 mu M toward carcinoma cell lines. Compound 2-(benzo[d]thiazol-2-ylthio)-1-(4-hydroxyphenyl)ethanone showed the highest selectivity cytotoxicity and it showed antioxidant effect with IC50 = 0.036 +/- 0.004 mg/mL. All compounds generally showed promising pharmacokinetic behaviors by obeying the various drug-likeness approaches.
- Journal
- PHARMACEUTICAL CHEMISTRY JOURNAL
- Year
- 2024
- Volume
- 57
- Issue
- 11
- Pages
- 1754-1760
- ISSN
- 0091-150X
- eISSN
- 1573-9031
- DOI
- 10.1007/s11094-024-03076-3
- WoS UID
- WOS:001186399600004