Article 2024 · 2 citations

Inflammatory parameters in NSCLC with driver mutation

Buyukbayram, Mehmet Emin, Hannarici, Zekeriya, Yilmaz, Ali, Turhan, Aykut, Caglar, Alperen Akansel, Esdur, Pinar Coban, Bilici, Mehmet, Tekin, Salim Basol

Abstract

Aim: The tumor microenvironment of NSCLC with driver mutations, such as EGFR, ALK and ROS, is less inflammatory. Materials & methods: This retrospective study included 38 patients with NSCLC driver mutations. The relationship between clinical and inflammatory markers concerning progression-free survival and overall survival was analyzed based on Kaplan-Meier curves. Results: The mean age of the patients was 59.8 +/- 11.9. Progression-free survival and overall survival were significantly longer in patients under 65 years of age and with low neutrophil-lymphocyte ratio, low systemic immune-inflammation index and high lymphocyte count (p < 0.05). Conclusion: Unlike tumor biology, peripheral inflammatory parameters, such as neutrophil-lymphocyte ratio, systemic immune-inflammation index and lymphocyte count may be associated with survival in NSCLC patients with driver mutations.

Keywords

driver mutation inflammatory markers non-small-cell lung cancer survival CELL LUNG-CANCER GROWTH-FACTOR RECEPTOR IMMUNE CHECKPOINT INHIBITORS DOCETAXEL NIVOLUMAB INDEX CHEMOTHERAPY SURVIVAL PHASE-3 PD-1

WoS Categories

Respiratory System

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: LUNG CANCER MANAGEMENT
Year: 2024
Volume: 13
Issue: 1
ISSN: 1758-1966
eISSN: 1758-1974
DOI: 10.2217/lmt-2023-0014
WoS UID: WOS:001176004900001

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