Virtual insights into the quercetin-<i> Melampsora</i> lini-derived effector AvrM14 interaction: An<i> In</i><i> silico</i> exploration of plant defense mechanisms
Shadidizaji, Azizeh, Cinisli, Kagan Tolga, Warda, Mohamad, Cicek, Betul, Hacimuftoglu, Ahmet
The co-evolutionary struggle between plants and pathogens shapes vital defense mechanisms crucial for survival. AvrM14 selectively removes the 5 ' cap from mRNA, disrupting key aspects of plant mRNA regulation, enhancing the flax rust fungus's infection capabilities. In contrast, quercetin, a plant flavonoid, serves as an antioxidant, stress reliever, and immune protector. This in silico study explores quercetin's inhibition of AvrM14, revealing high-affinity binding to the Nidux domain through molecular docking. Confirming stability in dynamic simulations, this pioneering research establishes quercetin as a functional AvrM14 inhibitor, suggesting its potential as a therapeutic agent against Melampsora lini's harmful impact on plant health.
- Journal
- PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY
- Year
- 2024
- Volume
- 129
- ISSN
- 0885-5765
- DOI
- 10.1016/j.pmpp.2023.102200
- WoS UID
- WOS:001144169100001