Design, physicochemical confirmation, single crystal structures as well as exploration of antibacterial and anticancer potential of organotin (IV) carboxylates
Gul, Roshni, Muhammad, Niaz, Sirajuddin, Muhammad, Noor, Awal, Tumanov, Nikolay, Wouters, Johan, Chafik, Abdelbasset, Solak, Kubra, Mavi, Ahmet, Shujah, Shaukat, Ali, Saqib, Khan, Gul Shahzada, Qayyum, Sadaf
In this article, we are reporting a series of di-and tri-organotin(IV) carboxylate complexes (1-4) derived from the reaction of sodium-3-bromophenylacetate (NaL) with (CH3)(2)SnCl2, (C4H9)(2)SnCl2, (CH3)(3)SnCl and (C4H9)(3)SnCl in dried toluene while refluxing for 8 h. The desired organotin(IV) derivative were analyzed by elemental analyzer, FTIR, NMR and single crystal XRD. The antimicrobial data against the tested bacterial strains follow the order: 2 > 4 > 3 > 1 > HL. The anticancer potential of the synthesized compounds was evaluated against the lung cancer cell line (A549) and normal lung fibroblast cell line (MRC-5) and it was observed that 4 was the highly cytotoxic against A549 while HL and 1 showed no cytotoxicity against MRC-5, neither at lower or higher concentrations.
- Journal
- JOURNAL OF MOLECULAR STRUCTURE
- Year
- 2024
- Volume
- 1300
- ISSN
- 0022-2860
- eISSN
- 1872-8014
- DOI
- 10.1016/j.molstruc.2023.137306
- WoS UID
- WOS:001140493700001