Comparison of the Effects of Two Different Low-Doses of Isobaric Bupivacaine on Intraoperative Hemodynamics under Spinal Anaesthesia during Caesarean Section: A Randomized Controlled Trial
Dostbil, Aysenur, Atalay, Canan, Ince, Ilker, Aksoy, Mehmet, Ozmen, Ozgur, Kasali, Kamber, Yapca, Omer Erkan, Kucun, Tugberk, Aksoy, Ayse Nur, Senocak, Gamze Nur Cimilli
<bold>Background</bold>: The objective of this study was to conduct a randomized controlled trial in order to examine the hemodynamic impacts of two different doses of intrathecal isobaric bupivacaine (5 mg and 7 mg) when combined with 15 mu g fentanyl in the context of patients undergoing caesarean section under combined spinal epidural anesthesia. <bold>Methods</bold>: Eighty patients with American Society of Anesthesiologists physical status I and II, aged between 16-50 years, who would undergo elective caesarean section under combined spinal epidural anaesthesia were randomly allocated to Group A and Group B (n = 40, for each group). Group A patients received a solution containing 5 mg isobaric bupivacaine + 15 mu g fentanyl (1.3 mL), while Group B patients received a solution containing 7 mg isobaric bupivacaine + 15 mu g fentanyl (1.7 mL) intrathecally. Incidences of hypotension, intraoperative systolic blood pressure, diastolic blood pressure, heart rate, motor block resolving time, and analgesia duration were recorded. <bold>Results</bold>: Group A had a substantially lower incidence of hypotension than Group B (p = 0.022). Patients in Group B had significantly lower systolic blood pressure values at the 6th, 8th, 10th, 12th, 14th, 15th, and 30th minutes of the surgery compared to Group A (p = 0.012, p = 0.014, p = 0.005, p = 0.016, p << 0,001, p = 0.002, and p = 0.011; respectively). Both groups had similar diastolic blood pressure and heart rate values during surgery (p >> 0.05). The motor block resolving time and analgesia duration were longer in Group B compared to Group A (p << 0.001 for both). Two (5%) patients in Group A and ten (25%) patients in Group B experienced postoperative itching (p = 0.012). <bold>Conclusions</bold>: We concluded that combining 5 mg isobaric bupivacaine with 15 mcg of fentanyl administered intrathecally provides adequate anaesthesia while maintaining better hemodynamic stability in patients undergoing caesarean section.
- Journal
- CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
- Year
- 2023
- Volume
- 50
- Issue
- 11
- ISSN
- 0390-6663
- eISSN
- 2709-0094
- DOI
- 10.31083/j.ceog5011241
- WoS UID
- WOS:001124027100019