Article 2023 · 1 citations

Predestinative role acidic cerebrospinal fluid on the destiny of central channel in spinal cord following subarachnoid hemorrhage: an experimental study

Sahin, Mehmet H., Akyuz, Mehmet E., Karadag, Mehmet K., Zeynal, Mete, Aydin, Mehmet D.

Abstract

Objective: Acidosis is the most dangerous complication in subarachnoid hemorrhage (SAH). This study aimed to investigate the effect of acidic cerebrospinal fluid on central canal structures after SAH. Materials and methods: Twenty-eight hybrid rabbits were studied. Blood and cerebrospinal fluid pH values were recorded before/during/after the experimental procedures. The structures related to the central canals at the level of C5 of the cervical spinal cord were then examined histopathologically. The relationship between pH values of ependymal cells and degenerated epithelial cell densities was statistically analyzed. Results: Mean blood pH values and degenerated ependymal cell density (n/mm2) were as follows: 7.351 +/- 0.033/23 +/- 7 in control, 7.322 +/- 0.059/78 +/- 13 in SHAM, and 7.261 +/- 0.048/254 +/- 62 in study animals. Gross examinations revealed swelling, edema, pia-arachnoid adhesions, ventral canal dilatation, arachnoiditis, central canal hemorrhage, occlusions, and dilatation in the spinal cord. Conclusion: Cerebrospinal fluid acidosis-induced central channel pathologies should be considered an important complication of SAH following SAH.

Keywords

Subarachnoid hemorrhage Ependymal cell desquamation Acidosis Cerebrospinal fluid CHOROID-PLEXUS ARTERY HYDROCEPHALUS DEGENERATION SYSTEM PH

WoS Categories

Surgery

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: CIRUGIA Y CIRUJANOS
Year: 2023
Volume: 91
Issue: 5
Pages: 627-632
ISSN: 0009-7411
DOI: 10.24875/CIRU.22000578
WoS UID: WOS:001108769300010

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