Article 2023 · 0 citations

Synthesis of alnustone-like diarylpentanoids via a 4+1 strategy and assessment of their potential anticancer activity

Celebioglu, Neslihan, Ozdemir Tozlu, Ozlem, Turkez, Hasan, Secen, Hasan

Abstract

Twelve compounds with a 1,5-diaryl-1-penten-3-one structure were synthesized and their cytotoxic activities were evaluated. The 1,5-diaryl-1-penten-3-one compounds were obtained via in situ enaminations of 4-phenyl-2-butanone and 4-(4-hydroxyphenyl)-2butanone in the presence of pyrrolidine-AcOH, followed by condensation with six different benzaldehydes. The synthesized compounds were tested for their cytotoxic activity against human glioblastoma (U87-MG), breast (MCF-7), and prostate (PC-3) cancer cell lines. Some of the novel compounds exhibited remarkable cytotoxic action, especially against MCF-7 cancer cells.

Keywords

1 5-Diarylpentanoid cytotoxic activity breast cancer prostate cancer glioblastoma anticancer effect CURCUMIN ANALOGS

WoS Categories

Chemistry, Multidisciplinary Engineering, Chemical

Sustainable Development Goals

Good Health and Well-being

Citation

Journal: TURKISH JOURNAL OF CHEMISTRY
Year: 2023
Volume: 47
Issue: 5
Pages: 1249-+
ISSN: 1300-0527
DOI: 10.55730/1300-0527.3609
WoS UID: WOS:001099801900028

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